A raucous collection of old friends descend on the Ortiz Funeral Home to pay respects to their beloved (and feared!) teacher Sister Rose – only to find her body has vanished. As the police grudgingly investigate, a legless priest, a mismatched gay couple, a womanizing DJ and a brain-damaged, Yodel-eating kid brother (not to mention Nasty Norca, the female predator) all reexamine their pasts – to settle scores, heal old wounds, ignite old passions or just unload emotional baggage.